Kai Kaila Selected Research

K Cl- Cotransporters

12/2018	Bumepamine, a brain-permeant benzylamine derivative of bumetanide, does not inhibit NKCC1 but is more potent to enhance phenobarbital's anti-seizure efficacy.
1/2016	Enhanced expression of potassium-chloride cotransporter KCC2 in human temporal lobe epilepsy.
4/2014	Inhibition of carbonic anhydrase augments GABAA receptor-mediated analgesia via a spinal mechanism of action.
6/2013	Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments.
6/2012	Modulation of spinal GABAergic analgesia by inhibition of chloride extrusion capacity in mice.
2/2010	Acetazolamide and midazolam act synergistically to inhibit neuropathic pain.

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Kai Kaila Research Topics

Disease

19	Seizures (Absence Seizure) 01/2022 - 12/2002
12	Epilepsy (Aura) 01/2021 - 08/2007
10	Asphyxia (Suffocation) 01/2022 - 11/2012
4	Acidosis 01/2021 - 11/2012
4	Temporal Lobe Epilepsy 01/2021 - 07/2003
4	Febrile Seizures (Febrile Seizure) 01/2020 - 07/2006
4	Hypercapnia 01/2020 - 08/2004
4	Wounds and Injuries (Trauma) 01/2015 - 04/2003
3	Inflammation (Inflammations) 01/2022 - 06/2012
3	Hypoxia (Hypoxemia) 01/2021 - 12/2016
3	Hypocapnia 01/2020 - 12/2003
3	Respiratory Alkalosis 01/2016 - 07/2006
3	Peripheral Nerve Injuries 04/2014 - 02/2010
2	Brain Diseases (Brain Disorder) 01/2022 - 01/2021
2	Pain (Aches) 01/2018 - 04/2014
2	Traumatic Brain Injuries (Traumatic Brain Injury) 01/2017 - 04/2014
2	Hyperthermia 01/2016 - 07/2006
2	Hyperalgesia 06/2012 - 02/2010
1	Mental Fatigue 12/2021
1	Cardiovascular Diseases (Cardiovascular Disease) 12/2021
1	Fatigue 12/2021
1	COVID-19 12/2021
1	Status Epilepticus (Complex Partial Status Epilepticus) 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2020
1	Progressive Myoclonic Epilepsies (Progressive Myoclonic Epilepsy) 01/2020
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2020
1	Migraine with Aura (Familial Hemiplegic Migraine) 01/2018
1	Headache (Headaches) 01/2018
1	Migraine Disorders (Migraine) 01/2018
1	Brain Hypoxia-Ischemia (Hypoxia Ischemia, Brain) 01/2017
1	Ischemia 12/2016
1	Hyperventilation 01/2016
1	Tonic-Clonic Epilepsy (Epilepsy, Tonic Clonic) 01/2016
1	Nervous System Diseases (Neurological Disorders) 04/2014
1	Alkalosis 11/2012
1	Hypersensitivity (Allergy) 06/2012

Drug/Important Bio-Agent (IBA)

7	Bumetanide (Bumex)FDA LinkGeneric 01/2022 - 04/2014
7	gamma-Aminobutyric Acid (GABA)IBA 06/2014 - 04/2003
6	Protein Isoforms (Isoforms)IBA 12/2018 - 08/2007
6	K Cl- CotransportersIBA 12/2018 - 02/2010
4	Carbonic Anhydrases (Carbonic Anhydrase)IBA 01/2021 - 02/2010
4	Pharmaceutical PreparationsIBA 01/2021 - 01/2011
4	AcidsIBA 01/2021 - 11/2011
4	Anticonvulsants (Antiepileptic Drugs)IBA 12/2018 - 02/2013
4	ChloridesIBA 06/2014 - 04/2003
3	Sodium Potassium Chloride Symporter Inhibitors (Loop Diuretics)IBA 01/2022 - 06/2013
3	Acetazolamide (Diamox)FDA LinkGeneric 01/2021 - 02/2010
3	Midazolam (Versed)FDA LinkGeneric 01/2021 - 02/2010
3	Diazepam (Valium)FDA LinkGeneric 01/2020 - 08/2013
2	Aminobutyrates (Aminobutyric Acid)IBA 01/2022 - 06/2014
2	Member 2 Solute Carrier Family 12IBA 01/2022 - 01/2021
2	Kainic Acid (Kainate)IBA 01/2021 - 01/2016
2	Phenobarbital (Luminal)FDA Link 01/2021 - 12/2018
2	Carbonic Anhydrase InhibitorsIBA 01/2021 - 04/2014
2	GasesIBA 01/2020 - 01/2020
2	Oxygen (Dioxygen)IBA 01/2020 - 01/2018
2	Pilocarpine (Ocusert)FDA LinkGeneric 12/2018 - 01/2016
2	Sodium-Potassium-Chloride SymportersIBA 12/2018 - 04/2014
2	Arginine Vasopressin (Argipressin)IBA 01/2018 - 01/2017
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 01/2017
2	CalpainIBA 12/2016 - 01/2015
2	Potassium Chloride FDA LinkGeneric 01/2016 - 04/2014
2	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2015 - 12/2002
2	CationsIBA 06/2014 - 04/2003
2	BenzodiazepinesIBA 06/2012 - 02/2010
1	Apolipoproteins E (ApoE)IBA 12/2021
1	ApolipoproteinsIBA 12/2021
1	Apolipoprotein E4IBA 12/2021
1	Ethoxzolamide (Ethamide)FDA Link 01/2021
1	BenzolamideIBA 01/2021
1	ProteomeIBA 01/2020
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2020
1	Histidine (L-Histidine)FDA Link 01/2020
1	Cystatin BIBA 01/2020
1	BumepamineIBA 12/2018
1	benzylamineIBA 12/2018
1	salicylhydroxamic acid (SHAM)IBA 01/2018
1	Phosphopyruvate Hydratase (Enolase)IBA 01/2017
1	Erythropoietin FDA Link 01/2017
1	Peptide Hydrolases (Proteases)FDA Link 12/2016
1	Dinoprostone (PGE2)FDA Link 01/2016
1	ProstaglandinsIBA 01/2016
1	EicosanoidsIBA 01/2016
1	PlasticsIBA 06/2014
1	DiureticsIBA 04/2014
1	ProdrugsIBA 04/2014
1	Formaldehyde (Formol)FDA Link 04/2014
1	EnzymesIBA 04/2014
1	Messenger RNA (mRNA)IBA 08/2013
1	Fluorescein (Funduscein)FDA LinkGeneric 11/2012
1	GABA-A Receptors (GABA(A) Receptor)IBA 06/2012
1	ganaxoloneIBA 06/2012

Therapy/Procedure

5	Therapeutics 11/2021 - 07/2006
2	Electrodes (Electrode) 01/2021 - 08/2004
2	Induced Hyperthermia (Thermotherapy) 01/2016 - 07/2006
1	Critical Care (Surgical Intensive Care) 12/2021
1	Drug Therapy (Chemotherapy) 01/2021
1	Aftercare (After-Treatment) 01/2018
1	Induced Hypothermia 01/2017
1	Analgesia 04/2014